实验室主任

王大平 博士
教授 | 博士生导师

学科:   骨科

单位:   深圳市第二人民医院

职务:   

1.政协深圳市第六届委员会副主席

2.深圳市公立医院管理中心主任  

3.致公党广东省委会副主委         

4.深圳市委会主委


  • 0755-83366388
  • 广东省深圳市福田区笋岗西路3002号
    • 骨科学,运动医学,组织工程学,生物材料学

王大平

博士 教授 博士生导师

  • 研究方向: 骨科学,运动医学,组织工程学,生物材料学
  • 学科: 骨科
  • 单位: 深圳市第二人民医院
  • 职务:

    1.政协深圳市第六届委员会副主席

    2.深圳市公立医院管理中心主任  

    3.致公党广东省委会副主委         

    4.深圳市委会主委


  • 电话: 0755-83366388
  • 邮箱: dapingwang1963@qq.com
  • 地址: 广东省深圳市福田区笋岗西路3002号

教育和工作经历

2012/6 - 至今,深圳大学附属第一医院,骨科,教授/博士生导师

1999/12 - 2012/5,深圳大学附属第一医院,骨科,教授/硕士生导师

1994/9 - 1995/4,英国曼彻斯特大学,霍普医院,访问学者

1988/9 - 1991/6,湖南医科大学,临床医学 博士

1985/9 - 1988/6,湖南医科大学,临床医学 硕士

1980/9 - 1985/7,湖南医科大学,临床医学 学士


1. 国家自然科学基金面上项目《ER/miR-140信号通路调控软骨基质代谢的分子机制研究》(No. 81572198 )2016-2019,57万元,主持

2. 广东省自然科学基金项目《TGF-β/miRNA-140/靶基因调控软骨基质代谢中的分子机制研究》(No. 2015A030313772 )2016-2018,10万元,主持

3. 深圳市科创委基础研究学科布局项目《基20170319 间充质干细胞代谢调控与骨基质修复的研究》(No. JCYJ20170413161649437), 2017-2020,250万元, 主持

4. 深圳市科创委基础研究学科布局项目《基20170092组织工程骨仿生活化及快速血管化研究》(No. JCYJ2017041361800287) 2017-2020,90万元, 合作主持

5. 深圳市科创委技术攻关项目《新型仿生骨材料的关键技术研发》(No.JSGG20151030140325149), 2016-2018, 192万元, 合作主持

6. 深圳市科创委技术攻关项目《个体化组织工程软骨治疗关节软骨缺损的关键技术研发》(No.JSGG2014051905550503), 2014-2016,300万元, 主持

7. 深圳市科创委国际合作项目《骨关节炎中相关miRNA调控机制研究》(No.GJHZ20130412159306739), 2013-2015, 80万元,主持

8. 卫生部,《国家临床重点专科(骨科)建设补助资金》, 2011-2014, 500万元,主持


     1.   Liangquan Peng, Yong Zhou, Wei Lu, Weimin Zhu, Yusheng Li, Kang Chen, Greg Zhang, Jian Xu, Zhenhan Deng and Daping Wang. Characterization of a novel polyvinyl alcohol/chitosan porous hydrogel combined with bone marrow mesenchymal stem cells and its application in articular cartilage repair. BMC Musculoskeletal Disorders (2019) 20:257.

     2.  Xu Xiao, Li Xingfu, Liang Yujie, Ou Yangkan, Huang Junfeng, Xiong Jianyi, Duan Li, Wang Daping. Estrogen Modulates Cartilage and Subchondral Bone Remodeling in an Ovariectomized Rat Model of Postmenopausal Osteoarthritis. Med Sci Monit, 2019; 25: 3146-3153.

     3.  Xu Jian, Liu Haifeng, Lu Wei, Zhu Weimin, Peng Liangquan, Ouyang Kan, Li Hao, Wang Daping. Clinical outcomes and radiologic assessment of a modified suture button arthroscopic Latarjet procedure. BMC Musculoskeletal Disorders (2019) 20:173.

     4.  Zhaofeng Jia, Feiyan Zhu, Xingfu Li, Qian Liang, Zhenjian Zhuo,Jianghong Huang, Li Duan, Jianyi Xiong, Daping Wang. Repair of osteochondral defects using injectable chitosan-based hydrogel encapsulated synovial fluid-derived mesenchymal stem cells in a rabbit model.

     5.Xu Zhengjiang, Long Jing, Zhang Ningfeng, Cao Huijuan, Tang Wei, Shi Keda, Wang Xinluan, Moya Sergio, Duan Li, Pan Haobo, Lai Yuxiao, Wang Daping, Wang Guocheng. Strong  mineralization ability of strontium zinc silicate: Formation of a continuous biomorphic mineralized layer with enhanced osteogenic activity. Colloids and Surfaces B: Biointerfaces 176 (2019) 420–430.

6.     Deng Zhiqin, Li Wencui, Xu Jianying, Yu Meishen, Li Duan, Tan Qiuchan, Wang Daping, Chen Lixin, Wang Liwei. ClC-3 chloride channels are involved in estradiol regulation of bone formation by MC3T3-E1 osteoblasts. J Cell Biochem. 2018;1-10.

7.     Kunyu Zhang, Zhaofeng Jia, Boguang Yang, Qian Feng, Xiao Xu, Weihao Yuan, Xingfu Li, Xiaoyu Chen, Li Duan, Daping Wang*, Liming Bian*. Adaptable hydrogels mediate cofactor-assisted activation of biomarker responsive drug delivery via positive feedback for enhanced tissue regeneration. Adv. Sci. 2018, 1800875 (#Co-correspondence)

8.       Zhaofeng Jia, Qisong Liu, Yujie Liang, Xingfu Li, Xiao Xu, Kan Ouyang, JianyiXiong, Daping Wang*, Li Duan. Repair of articular cartilage defects with intra‑articular injection of autologousrabbit synovial fluid‑derived mesenchymal stem cells. J Transl Med. 2018, 16:123.

9.      Zhaofeng Jia, Yujie Liang, Xiao xu, Xingfu Li, Qisong Liu, Yangkang OU, Li Duan, Weimin Zhu, Wei Lu, JiangyiXiong, Daping Wang*. Isolation and characterization of human mesenchymal stem cells derived from synovial fluid by magnetic activated cell sorting (MACS). Cell Biology International. 2018,42(3).262-271

10.   Zhaofeng Jia, Yujie Liang, Xingfu Li, Xiao xu, JiangyiXiong, Daping Wang*, Li Duan. Magnetic-activated cell sorting strategies to isolate and purify synovial fluid-derived mesenchymal stem cells from a rabbit model. Journal of Visualized Experiments.2018, (138), e57466, doi:10.3791/57466.

11.   Yong He, Wei Liu, Lianxiong Guan, Jielin Chen, Li Duan, ZhaoFeng Jia, Jianghong Huang, Wencui Li, Jianquan Liu, JianyiXiong, Lijun Liu, Daping Wang*.A Novel 3D-printed PLCL Scaffold Coated with Collagen Type I for Tissue Engineering Applications.BioMed Research International. 2018(2018):1-10

12.   Jianghong Huang,Yujie Liang, Meiquan Xu, JianyiXiong, Daping Wang*, Qiang Ding*. MicroRNA-124 Acts as a Tumor-suppressive miRNA by Inhibiting the Expression of Snail2 in Osteosarcoma. Oncology Letters, 2018, 15(4):4979-4987

13.   Jianghong Huang, Wei Liu, Yujie Liang, Long Li, Li Duan, Jielin Chen, Feiyan Zhu, Yuxiao Lai, Weimin Zhu, Wei You, ZhaoFeng Jia, JianyiXiong*, Daping Wang*. Preparation and Biocompatibility of Diphasic Magnetic Nanocomposite Scaffold Materials. Materials Science and Engineering C. 2018,87:70-77

14.   Gaorui Cai, Wei Liu, Yong He, Jianghong Huang, Li Duan, Jianyi Xiong, Lijun Liu & Daping Wang (2018): Recent advances in kartogenin for cartilage regeneration, Journal of Drug Targeting, DOI: 10.1080/1061186X.2018.1464011.

15.   He Yong Liu Wei Guan Lianxiong Chen Jielin Duan Li Jia Zhaofeng Huang Jianghong Li Wencui Liu Jianquan Xiong Jianyi Liu Lijun Wang Daping. A 3D-Printed PLCL Scaffold Coated with Collagen Type I and Its Biocompatibility. BioMed Research International 2018, 5147156.

16.   Jianghong Huang, Yujie Liang, ZhaoFeng Jia, Jielin Chen, Li Duan, Wei Liu, Feiyan Zhu, Qian Liang, Weimin Zhu, Wei You, Jianyi Xiong, and Daping Wang. Development of Magnetic Nanocomposite Hydrogel with Potential Cartilage Tissue Engineering. ACS Omega 2018, 3, 6182−6189.

17.   Qisong Liu, Zhaofeng Jia, Li Duan, JianyiXiong, Daping Wang*, Yue Ding*. Functional peptides for cartilage tissue engineering. American Journal of Translational Research. 2018;10(2):501-510.

18.   Kuai S, Guan X, Zhou W, Zhang R, Ji R, Liao Z, Guo D, Liu W, Wang D. Continuous lumbar spine rhythms during level walking, stair climbing and trunkflexion in people with and without lumbar disc herniation. Gait Posture. 2018, 06 ;63

19.   Zhaofeng Jia,Yujie Liang,Bin Ma,Xiao Xu,Jianyi Xiong,Li Duan,Daping Wang*. A 5-mC Dot Blot Assay Quantifying the DNA Methylation Level of Chondrocyte Dedifferentiation In Vitro. Journal of Visualized Experiments.2017, (123). doi: 10.3791/55565.

20.   Li Duan, Yujie Liang, Bin Ma, Daming Wang, Wei Liu, Jianghong Huang, JianyiXiong, Liangquan Peng, Jielin Chen, Weimin Zhu, Daping Wang*. DNA Methylation Profiling in Chondrocyte Dedifferentiation In Vitro. Journal of Cellular Physiology.2017,232:1708-1716.

21.   Daming Wang, Wei Liu, Qian Feng, Chaoqun Dong, Qisong Liu, Li Duan, Jianghong Huang, Weimin Zhu, Zemeng Li, JianyiXiong, Yujie Liang, Jielin Chen, Rong Sun, Liming Bian, Daping Wang*. Effect of inorganic/organic ratio and chemical coupling on the performance of porous silica/chitosan hybrid scaffolds. Materials Science and Engineering C. 2017; 70 :969–975

22.   Wei Liu, Daming Wang, Jianghong Huang, You Wei, JianyiXiong, Weimin Zhu,Li Duan, Jielin Chen, Rong Sun, Daping Wang*. Low-temperature deposition manufacturing: A novel and promising rapid prototyping technology for the fabrication of tissue-engineered scaffold. Materials Science and Engineering C. 2017; 70 :976–982.

23.   Daiqi Guo, Shengzheng Kuai, Wenyu Zhou, Xinyu Guan, Zhenhua Liao, Weiqiang Liu, Daping Wang. Intersegmental coordination in lower extremities and multi-segmental spine during different activities of daily living. Journal of Mechanics in Medicine and Biology.2017

24.   Jianghong Huang, Daming Wang, Jielin Chen, Wei Liu, Li Duan, Wei You, Weimin Zhu, JianyiXiong, Daping Wang*. Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by Magnetic Nanoparticle Composite Scaffolds under a pulsed electromagnetic Field. Saudi Pharmaceutical Journal, 2017, 25:575-579

25.   Cui Jiaming Lu Wei He Yong Jiang Luoyong Li Kuokuo Zhu Weimin Wang Daping. Molecular biology of frozen shoulder-induced limitation of shoulder joint movements. J Res Med Sci 2017;22:61.

26.   Jian Xu, Xin Ma, Daping Wang, Wei Lu, Weimin Zhu, Kan Ouyang, Haifeng Liu, Hao Li, Luoyong Jiang. Comparison of Extraosseous Talotarsal Stabilization Implants in a Stage II Adult-Acquired Flatfoot Model: A Finite Element Analysis. The Journal of Foot & Ankle Surgery 56 (2017) 1058–1064.

27.   Jie-Lin Chen, Chang Zou, Yunfang Chen, Weimin Zhu, Wei Liu, Jianghong Huang, Qisong Liu, Daming Wang, Li Duan, Jianyi Xiong, Jiaming Cui, Zhaofeng Jia and Daping Wang. TGFβ1 induces hypertrophic change and expression of angiogenic factors in human chondrocytes. Oncotarget, 2017, Vol. 8, (No. 53), pp: 91316-91327

28.   Zhaofeng Jia, Yujie Liang, Xiao Xu, Xingfu Li, Qisong Liu,Yangkan Ou, Li Duan, Weimin Zhu, Wei Lu, Jianyi Xiong, Daping Wang. Isolation and characterisation of human mesenchymal stem cells derived from synovial fluid by magnetic activated cell sorting (MACS)† Running Head: Isolation of hSF-MSCs by MACS. Cell Biology International, 10.1002/cbin.10903

29.   Yongyu Ye, Wei You, Weimin Zhu, Jiaming Cui, Kang Chen, and Daping Wang. The Applications of Finite Element Analysis in Proximal Humeral Fractures. Computational and Mathematical Methods in Medicine Volume 2017, Article ID 4879836, 9 pages.

30.   Xiaomei Meng, Yaozhong Dong, Xiao Yu, Daping Wang, Shaoguang Wang, Shulin Chen, Shuguang Pang. MREG suppresses thyroid cancer cell invasion and proliferation by inhibiting Akt-mTOR signaling. Biochemical and Biophysical Research Communications 491 (2017) 72e78.

31.   JIAMING CUI, TONGDA ZHANG, JIANYI XIONG, WEI LU, LI DUAN, WEIMIN ZHU and DAPING WANG. RNA‑sequence analysis of samples from patients with idiopathic adhesive capsulitis. MOLECULAR MEDICINE REPORTS 16: 7665-7672, 2017.

32.   Yujie Liang, Li Duan, Qisongliu, Weiming Zhu, JianyiXiong, Zigang Li*, Daping Wang*. E2 regulates MMP-13 via targeting miR-140 in IL-1β-induced extracellular matrix degradation in human chondrocytes. Arthritis Research & Therapy. 2016; 18(1): 105.

33.   Xingfu Li, Li Duan, Yujie Liang, Weimin Zhu, JianyiXiong*, Daping Wang*. Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Contribute to Chondrogenesis in Coculture with Chondrocytes. Biomed Res Int. 2016: 3827057.

34.   Xinle Luo, Weimin Zhu, Jiaming Cui, JieLin Chen,Liangquan Peng, Jianyi Xiong, Weili Xu, Yanjun Zeng, and Daping Wang. Mutagenicity test of magnetic nanocomposite for interface fixation. Nanomaterials and Nanotechnology Volume 6: 1–3.

35.   Weimin Zhu, Daiqi Guo, Liangquan Peng, Yun Fang Chen, Jiaming Cui, Jianyi Xiong, Wei Lu, Li Duan, Kang Chen, Yanjun Zeng & Daping Wang. Repair of rabbit cartilage defect based on the fusion of rabbit bone marrow stromal cells and Nano-HA/PLLA composite material. ARTIFICIAL CELLS, NANOMEDICINE, AND BIOTECHNOLOGY, 2016.

36.   DamingWang, Wei Liu, Qian Feng, Chaoqun Dong, Qisong Liu, Li Duan, Jianghong Huang, Weimin Zhu, Zemeng Li, Jianyi Xiong, Yujie Liang, Jielin Chen, Rong Sun, Liming Bian, DapingWang. Effect of inorganic/organic ratio and chemical coupling on the performance of porous silica/chitosan hybrid scaffolds. Materials Science and Engineering C xxx (2016) xxx–xxx.

37.   Zhu Weimin, Chen Jie-Lin, Cui Jiaming, Huang Jianghong, Xiong Jianyi, D u a n L i, and Wang Daping. Effects of Sulforaphane on Human Chondrocytes Cultured In Vitro. Journal of Biomaterials and Tissue Engineering, Vol. 6, 1–8, 2016.

38.   Kan Ouyang, Daping Wang, Wei Lu, Jianyi Xiong, Jian Xu, Liangquan Peng, Haifeng Liu1, Hao Li and Wenzhe Feng. Arthroscopic reduction and fixation of coronoid fractures with an exchange rod—a new technique. Journal of Orthopaedic Surgery and Research (2017) 12:9.


(1), Li Duan, Daming Wang, Wei Liu. Extracellular Matrix-derived Implants in Clinical Medicine (Chapter 5: Extra-cellular matrix derived tissues for hard tissue repair),Woodhead Publishing,10 千字,2016

(2)肖建德,,陆伟,运动医学常见疾病的诊断与关节镜治疗,湖南科学技术出版社,400千字,2011

(3)肖建德,,陆伟,运动项目及相关损伤,湖南科学技术出版社,330千字,2011

(4) 肖建德,,陆伟,肩关节运动医学常见疾病影像学图谱,湖南科学技术出版社,150千字,2011

(5) 肖建德,,陆伟,膝关节运动医学常见疾病影像学图谱,湖南科学技术出版社,130千字,2011

(6) 肖建德,,陆伟,运动性疾病,湖南科学技术出版社,108千字,2011


小分子novel-miR-1和骨肉瘤药物 ZL201410705474.6

骨肉瘤的生物标记物及其应用 ZL201410699583.1

一种EXT1基因突变序列. ZL 201410364178.4

磁性纳米多孔复合骨组织工程支架材料及其制备方法.ZL 201310431866.3

一种组织工程骨移植物及其构建方法.ZL 200910107624.2

一种骨折复位外固定支架,ZL200710074846.X

包裹固定作用力可调式小白鼠暂存夹 专利申请号:201710966052.8

封闭式兔子养殖箱 专利申请号:201710966061.7

通用型实验室鼠笼 专利申请号:201710966054.7

兔耳防咬伤防护组件 专利申请号:201710967630.X

一种大鼠断头取血操作台 专利申请号:201710966053.2

一种鳞片式防咬防护型手套 专利申请号:201710977787.0

一种三通道大鼠喂食器 专利申请号:201621278650.3

一种大鼠抓取手套,专利申请号:201621286412.7

一种自由组合式鼠笼,专利申请号:201621290084.8

一种猪软骨打孔器,专利申请号:201621267509.3

一种大鼠取血装置,专利申请号:201621291057.2

一种口控毛细管单细胞分离装置,专利申请号:201621278662.6

一种大鼠打药箱,专利申请号:201621285948.7

大鼠箱清理”,专利申请号:201621278320.4

一种便携式大鼠断头取血器,专利申请号:201621278386.3

多功能大鼠实验台,专利申请号:201621278352.4

一种大鼠饮水器,专利申请号:201621267475.8

一种软骨固定器,专利申请号:201721335122.1

一种兔耳防咬圈,专利申请号:201721336609.1

封闭式兔箱 ,专利申请号:201721335117.0

一种多功能小鼠暂存夹,专利申请号:201721349654.0

软骨粉碎器 ,专利申请号:201721335103.9

兔腿固定器 ,专利申请号:201721336662.1

简易废液收集器,专利申请号:201721335104.3

兔腿防抓套 ,专利申请号:201721336668.9

兔皮牵拉器 ,专利申请号:201721335116.6

一种样品脱钙袋 ,专利申请号:201721335102.4

一种防溅防缠分线装置 ,专利申请号:201721335121.7

多功能标记牌 ,专利申请号:201721335105.8

新型化学实验废液收集装置 ,专利申请号:201721335101.X


1.组织工程化软骨移植体系的建立及推广应用,中华医学会,中华医学科技奖,三等奖,2017.

2.个体化MACI技术的研发及其在关节软骨缺损治疗中的应用,广东省科技厅,广东省科学技术奖,三等奖,2015.;

3.活性纳米组织工程化人工骨的系列研究,深圳市人民政府,深圳市科技进步奖,二等奖,2015;

4.个体化基质诱导软骨细胞移植基础与临床研究,深圳市人民政府,深圳市科学技术奖,二等奖,2013;

5.荣获中国产学研合作创新奖,科技部和国家科技奖励办,2016